IIS Server, sudden 404.4 on all sites The resource you are looking for does not have a handler associated with it

I have a long standing IIS 7.5 box that suddenly stopped working mid morning today. Something has obviously changed but I have been unable to determine what and would appreciate any suggestion.

All of the sites on the IIS server have started returning the same error page when viewed locally –
HTTP Error 404.4 – Not Found
The resource you are looking for does not have a handler associated with it.

The server has a number of web sites on it, mostly asp.net but there are some others.

Things I have tried (in no particular order) –

I’m at a loss now for ideas so would appreciate any suggestions.

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Author: Steve